Stanford, Calif. - Conjugation of cyclosporin A to arginine oligomer protein transduction sequences provides a promising method for delivery of the peptide immunosuppressant agent into psoriatic skin. However, further study is needed to characterize the cutaneous bioavailability achieved with that novel delivery platform and to answer the larger question of whether topical cyclosporin A offers a viable therapeutic modality for psoriasis, according to David F. Fiorentino, M.D., Ph.D.
The FDA approval, based on 36-week data from the phase 3 BRAVE-AA-PEDS trial, extends baricitinib access to patients as young as 12 years old with severe alopecia areata.
The FDA approved therapies for melanoma, dermatomyositis, superficial basal cell carcinoma, and adolescent alopecia areata, while TYK2 inhibitors and rare disease filings advanced toward 2027 decisions.