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Hyperbaric oxygen therapy reduces amputation risk in chronic wounds


As the population ages, physicians are seeing a surge in the prevalence of chronic, nonhealing wounds because of the increase in disease processes leading to wounds, an expert says.

Buffalo, N.Y. - As the population ages, physicians are seeing a surge in the prevalence of chronic, nonhealing wounds because of the increase in disease processes leading to wounds, an expert says.

“A chronic or nonhealing wound is typically the end result of a number of comorbid conditions at play at the same time,” says Lee Ruotsi, M.D., F.A.C.C.W.S., U.H.M., medical director, Catholic Health Advanced Wound Healing Centers, Catholic Health System of Western New York, Buffalo, N.Y. “The wound then fails to heal due to these conditions in addition to other local factors, such as infection, moisture, recurrent trauma and swelling.”

Targeted treatment
Specific categories of chronic wounds have been found to respond to treatment with hyperbaric oxygen: diabetic foot ulcers, arterial insufficiency ulcers, delayed radiation injuries, osteomyelitis, failed or failing skin grafts and flaps, and necrotizing fasciitis.

“What’s really important to understand is that just because somebody has a wound doesn’t mean that hyperbaric oxygen therapy is the right treatment for that wound,” Dr. Ruotsi says. “It needs to be a wound that is failing to heal because it is receiving inadequate blood flow, depriving the wound of necessary oxygen.”

Misconceptions persist about hyperbaric oxygen therapy.

“Hyperbaric oxygen therapy is a therapy in which the patient breathes 100 percent oxygen while inside a treatment chamber at greater than atmospheric pressure,” he says.

In contrast, people often believe that physicians treat wounds by enclosing an individual limb in a sealed container and filling the container with pressurized oxygen.

“The key to hyperbaric oxygen therapy is that the oxygen is delivered through an intact circulatory system to the site of injury, not squeezed into the wound externally,” Dr. Ruotsi says.

Patient selection
Before choosing this option, it’s important to determine which patients would be most likely to benefit from hyperbaric oxygen treatment. For example, diabetic foot ulcers must be of a specific severity, whereas efforts toward revascularization are necessary before hyperbaric oxygen therapy for arterial insufficiency ulcers.

In addition, to assess the potential effectiveness of oxygen treatment, Dr. Ruotsi says he applies electrodes to the skin around the wound to measure oxygen tension. If the number exceeds 50 mmHg PO2, he says he may not use hyperbaric oxygen treatment, because he expects the wound to heal on its own with good woundcare; however, a low value indicates that the wound may be failing to heal because of an insufficient oxygen supply.

Next, Dr. Ruotsi performs an oxygen challenge. The patient breathes from a high-flow oxygen mask for 10 minutes, and then Dr. Ruotsi retests the wound area. If oxygen values increase, he deduces the patient has an adequate circulatory supply to the area in question and may benefit from hyperbaric oxygen treatment. If levels remain below normal, he refers the patient to a vascular specialist. If the specialist is able to improve the circulation, then the patient may become a candidate for hyperbaric oxygen therapy.

Increased comfort
Over the years, hyperbaric treatments have become more patient-friendly. “Hyperbaric chambers are now more sophisticated, comfortable and safer than in years past,” Dr. Ruotsi says.

Earlier versions tended to be steel chambers with small portholes. Patients now lie on a reclining bed inside a transparent acrylic chamber and can watch flat-screen televisions mounted on the ceiling.

Boosting success
A number of strategies can increase the success of hyperbaric oxygen treatment in wound healing.

It’s important that smokers stop smoking completely. “Smoking is a powerful detriment to wound healing and can effectively negate the benefits of hyperbaric treatment,” Dr. Ruotsi says.

In some cases, he asks patients to sign consent forms that allow him to check their nicotine levels within two to three weeks after treatment begins.

“Hyperbaric oxygen is a fairly expensive modality, and there’s no sense offering it to people if they’re not going to, at least to some extent, do their part,” he says.

Diabetic patients should control their blood sugar levels as well as possible. In diabetic patients with arterial insufficiency ulcers, vascular surgeons or endovascular specialists should optimize patients’ vascular status to be sure the vascular supply to the wound is as good as it can possibly be, Dr. Ruotsi says.

Long-term benefits
Ultimately, hyperbaric oxygen treatment can yield tremendous benefits in reducing the risk of amputation in patients with chronic, nonhealing wounds. Nationwide studies have shown that there is an increased healing rate and reduced rate of amputations in wound centers with hyperbaric oxygen capability. “That’s really what this is all about, to avoid lower extremity amputation in diabetics or people with peripheral arterial disease,” Dr. Ruotsi says.

Disclosures: Dr. Ruotsi reports no financial interests.

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