Cosmetic Conundrums: 'ObNOXious' aging: Collagen-destroying enzyme increases with advancing age

May 1, 2009

ArNOX is an abbreviation for age-related NOX, with NOX representing NADH oxidase proteins. Much of the research on arNOX was completed by D.M. Morré, Ph.D., and D.J. Morré, Ph.D., at Purdue University, West Lafayette, Ind. Several types of NOX have been identified, including constitutive or normal NOX (cNOX) and tumor NOX (tNOX).

Key Points

Q: What is arNOX?

ArNOX is protein with increasing activity with advancing age. It is an enzyme that is located on the external cell surface, capable of being shed into the circulation. ArNOX has been found in all cells and fluids tested, including the keratinocytes, fibroblasts, saliva, serum, perspiration and urine.

ArNOX activity increases beginning at age 35 to 45 years. It is at this age that visible signs of aging begin.

ArNOX measurements represent an interesting methodology to study aging. ArNOX levels could be used to study the relationship between intrinsic and extrinsic aging. Further, arNOX represents a target for antiaging treatments, and it provides an opportunity for the development of new ingredients for both internal consumption and external application. Research is currently ongoing.

Q: How do hair-removing gloves work?

A: Hair removing gloves, work by mechanically breaking the hair at the skin surface. The glove is rough and has a sticky surface that grabs the hair shaft. The mechanical motion of rubbing breaks the hair.

A Zoe Diana Draelos, M.D., is a Dermatology Times editorial adviser and investigator, Dermatology Consulting Services, High Point, N.C.

Questions may be submitted via e-mail to zdraelos@northstate.net
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