This week’s collection of the latest dermatologic studies covers dermatologic care for patients with disorders of sex development, stem cell transplantation for vitiligo, switching biologic therapies for psoriasis, and combination therapy for hidradenitis suppurativa.
Gold et al investigated the importance of dermatologic care in the multidisciplinary treatment of disorders of sex development (DSD). In their review, the authors studied Klinefelter syndrome, Turner syndrome, congenital adrenal hyperplasia, androgen insensitivity syndrome, 5-Aplha reductase deficiency, and more. According to the authors, refractory leg ulcer and incontinentia pigmenti have been described in Klinefelter syndrome, Turner syndrome can be associated with lymphatic malformations, halo nevi, dermatitis, and psoriasis, Virilization has been seen in some forms of congenital adrenal hyperplasia where acne and hirsutism are also common.
Researchers in China selected 50 patients with vitiligo who were treated from June 2021 to March 2022 with a disease duration of 1 to 20 years and no response to other vitiligo therapies to participate in a hair follicle melanocyte stem cell transplantation trial. Fifty patients in the treatment group were treated with hair follicle melanocyte stem cell transplantation combined with a 308-excimer laser once a week, and 50 patients in the control group were treated only with a 308-excimer laser once a week. In the treatment group, 92% of patients saw improvement in repigmentation.
Clemmesen et al sought to “examine disease- and treatment-related intra- and interpersonal factors and their relation to treatment expectations among patients with psoriasis who initiate or switch biological therapy.” The study authors instructed adult patients with moderate to severe psoriasis who had initiated or switched biologic therapy to complete a questionnaire about their disease and treatment-related expectations. Patients also completed Patients' Attitudes and Beliefs Scale, Trust in Physician Scale, Dermatology Life Quality Index questionnaires, and Psoriasis Area Severity Index. Out of 65 completed surveys, 28% of patients expected <90% clearance of psoriasis following treatment, and 72% expected 90% to 100% clearance.
Mostafa et al completed a literature review of existing hidradenitis suppurativa (HS) and reviewed case reports, case series, cohort studies, or clinical trials of patients with HS who were treated with combination therapy, defined as 2 or more systemic medical treatments. In total, 19 articles were examined. In their literature review, the authors collected data on clindamycin and rifampicin, rifampicin-moxifloxacin-metronidazole, and combinations with at least one antibiotic. Mostafa et al concluded that there is evidence that combination therapy may be effective for HS, and that larger, more robust studies are needed.
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