Topical halobetasol propionate 0.01% lotion (Bryhali, Bausch Health) appears to safely and quickly improve lower-extremity psoriatic lesions, according to findings reported recently in the Journal of Drugs in Dermatology.1
A post hoc analysis of data from phase 3 studies investigating the efficacy of halobetasol propionate 0.01% lotion for treating moderate-to-severe plaque psoriasis showed that the topical corticosteroid was associated with rapid improvement, and findings should help dermatologists with treatment decisions for patients with disease involving leg lesions, said Neal Bhatia, M.D., director of clinical dermatology at Therapeutics Clinical Research, San Diego, and the lead author of the paper.
At the end of the eight-week treatment period, rates of treatment success and overall treatment success were significantly higher for patients randomized to once-daily treatment with halobetasol 0.01% lotion compared with vehicle-treated controls (P<.001 for both comparisons).
“Many patients with psoriasis experience stubborn plaques on the legs,” Dr. Bhatia says. “Past studies measuring changes in PASI scores have shown more rapid improvement of plaques involving the head and trunk compared to the lower extremities. This subgroup analysis demonstrated a reasonable and sustained response was achieved using halobetasol 0.01% lotion for lesions on the legs.”
It was encouraging to see that the logion was effective at improving disease on a larger, hair-bearing area of the skin, he adds.
Dr. Bhatia is an advisor and/or investigator for Bausch Health.
1. Bhatia ND, Vlahovic TC, Green LG, Martin G, Lin T. J Drugs Dermatol. 2019;18(10):1029-1036