A study showing differences in baseline characteristics between responders to anti-tumor necrosis factor (anti-TNF) therapy and insufficient responders may be helpful to dermatologists as they consider treatment for patients with moderate-to-severe psoriasis, according to the investigators.
The research analyzed data from patients enrolled in the Corrona Psoriasis Registry.1 In an adjusted analysis, female sex was the only baseline characteristic that was independently associated with a decreased likelihood of achieving a response to anti-TNF therapy at 6 months. However, a number of other imbalances were noted at enrollment between the responders and patients who had an insufficient response to anti-TNF therapy. The investigators suggest that awareness of these differences may help clinicians identify patients with moderate-to-severe psoriasis whose needs may not be met by an anti-TNF agent and who instead may benefit from a different approach to care and/or a biologic with a different mechanism of action.
Providing information to explain the background for conducting the study, researchers note that anti-TNF agents are often used as first-line biologic treatment for psoriasis. In addition, it is common for patients to be switched to another anti-TNF agent if they do not respond adequately to the initial therapy. They wrote, “Switching or discontinuing anti-TNFs has significant implications for clinical and economic outcomes in patients with psoriasis; therefore, real-world studies that characterize patients on the basis of response to therapy would provide valuable information to help healthcare providers.”
To conduct a “real-world” study, they extracted data from the prospective Corrona Psoriasis Registry, which enrolls adults diagnosed with psoriasis by a dermatologist who started or switched to and continued a systemic or biologic agent within the previous 12 months that has an FDA-approved indication for treating psoriasis.
Patients were included in the analysis if they had moderate-to-severe disease, defined as affected body surface area (BSA) ≥3%, entered into the registry between April 2015 and June 2018 upon starting anti-TNF therapy, and had at least one 6-month follow-up visit. Patients were identified as insufficient responders if at 6 months their affected BSA was ≥3% or improved <75% from baseline. Patients who had discontinued or were switched from their initial anti-TNF agent were also classified as insufficient responders.
1. Van voorhees AS, Mason MA, Harrold LR, et al. Characterization of insufficient responders to anti-tumor necrosis factor therapies in patients with moderate to severe psoriasis: real-world data from the US Corrona Psoriasis Registry. J Dermatolog Treat. 2019;:1-8.