CELLULAR SKIN THERAPY
Military and other amputees can have difficulty wearing prostheses, Dr. Chien says, because stumpsite skin is more fragile and lacks the characteristics of volar skin of the hands and feet. Luis Garza, M.D., Ph.D., associate professor of dermatology, is exploring whether one can reprogram skin cells to develop palm and sole characteristics on stump sites. Such skin can better sustain the day-to-day use of a prosthesis without breaking down, Dr. Chien says.
“The issue these days in cosmetic dermatology is that there are so many injectables and devices. They come out fairly quickly. But mechanisms and how they really work are not as well known.”
Colleagues led by Mary Sheu, M.D., assistant professor of dermatology, are interested in understanding the mechanisms and science behind aesthetic procedures. She found that shortly after non-ablative fractional laser treatment, one could use now-proprietary biomarkers to indicate which patients would respond better to treatment over time.
Dr. Chien says, “We now know that if you hit a certain target early, that might give the biggest improvement from an antiaging standpoint.”
The program collaborates with Unilever, which hopes to learn if these biomarkers can be targeted to improve patients’ skin.2
Dr. Chien reports no relevant fi nancial interests. The CTReP has received grants from Galderma, Johnson & Johnson, L’Oreal, Kyocera, Lutronic, Mela Sciences, Pfizer, SkinMedica, Unilever and Walgreens Boots Alliance.
1. Rainer B, Qi J, Martin J, et al. Visible light-induced hyperpigmentation in human skin in vivo occurs in dark, but not in light skin, and is associated with differential induction of CCL18 and tyrosinase genes. Society for Investigative Dermatology Annual Meeting. May 6-9, 2015. Atlanta.
2. Sheu M. Biomarkers activated with fractionated laser. Photomedicine Society Annual Meeting. February 28, 2019. Washington, D.C.
3. OkoyeGA,Rainer BM,Leung SG, et al. Improvingacnekeloidalis nuchae with targeted ultraviolet B treatment: a prospective, randomized, split-scalp comparison study. Br J Dermatol.2014;171(5):1156-63.