Subgroup 2: Hospital-diagnosed severe psoriasis:
- Hypercholesterolemia showed a strong association with psoriasis (adjusted OR 2.71; 1.41–6.41)
- Hypertension was not associated with severe psoriasis (adjusted OR 1.12; 0.44–2.87)
- Metabolic syndrome did not show an association with severe psoriasis (adjusted OR 4.63; 1.38–15.47).
This study adds to the growing literature linking cardiometabolic disease and psoriasis. In this study, however, dyslipidemia was the only cardiovascular risk factor that remained elevated after adjusting for age, smoking and BMI. Suggesting that other cardiometabolic morbidity is mainly associated with traditional risk factors.
The take home message of this study is that, in this large retrospective Danish cohort, cardiometabolic disease was common in patients with psoriasis. When adjusting for BMI, smoking and age, hypercholesterolemia was associated with psoriasis. However, more patients in the psoriasis cohort were also smokers and had elevated BMIs increasing the risk of cardiometabolic disease.
In practice, patients of all ages who suffer from psoriasis should have traditional cardiometabolic risk factors addressed. This includes diet, exercise and smoking cessation. Furthermore, psoriasis patients should be evaluated for hypertension, diabetes and dyslipidemia and treated accordingly.
Blegvad C, Nybo andersen AM, Adam A, et al. Psoriasis as a Predictor of Cardiometabolic Comorbidity in Women: A Study Based on the Danish National Birth Cohort. Acta Derm Venereol. 2019;99(3):274-278.