It is well established that psoriasis is associated with cardiometabolic disease, though the reason why remains unclear. It is thought that the systemic inflammation linked to the immune-mediated skin disorder may lead to accelerated atherosclerosis, insulin resistance and, eventually, cardiovascular diseases, such as stroke and heart attack.
Recently, researchers led by Christoffer Blegvad, M.D., used the Danish National Birth Cohort to explore the association between psoriasis and cardiometabolic disease in pregnant women and mothers. Of the 85,000 mothers from the cohort, 2,435 reported having psoriasis (2.9%). The study authors used statistical analysis to reduce confounders such as age, body mass index (BMI) and smoking. For more information on the study methods, click here.
The women with psoriasis were found to have the following associated the comorbidities:
Subgroup 1: Self-reported cardiometabolic disease:
- Hypercholesterolemia was significantly associated with psoriasis even after adjusting for confounders (adjusted OR 1.31; 1.01–1.70).
- Hypertension was not associated with psoriasis (adjusted OR 0.95; 0.76–1.19).
- Type 2 diabetes mellitus was not associated with psoriasis (BMI <25 and >25 adjusted OR 0.60; 0.15–2.44, 0.94; 0.45–1.94 respectively).
- Metabolic syndrome was not associated with psoriasis (adjusted OR 0.93; 0.55–1.58).
Blegvad C, Nybo andersen AM, Adam A, et al. Psoriasis as a Predictor of Cardiometabolic Comorbidity in Women: A Study Based on the Danish National Birth Cohort. Acta Derm Venereol. 2019;99(3):274-278.