Psoriasis has been strongly linked to metabolic and Type 2 diabetes, but the exact relationship between psoriasis and Type 2 diabetes remains ambiguous.
Jesper Holm, M.D. and colleagues from the Department of Dermato-Venereology at Bispebjerg Hospital in Copenhagen Denmark studied the link between Type 2 diabetes and psoriasis to better understand the pathophysiology, and provide a better understanding of the link between the two diseases.
This study was performed as a systematic review, in which articles indexed in PubMed were searched for using the keywords “psoriasis,” “diabetes,” “risk,” “link” and “association.” The review included all clinical literature on this topic in English from case reports to randomized controlled trials. Reviews, however, were excluded.
Researchers analyzed 15 epidemiologic psoriasis cohorts. The average prevalence of Type 2 diabetes across psoriasis cohorts was 11.6%, but there was no apparent association between Type 2 diabetes prevalence and mean patient age (n=15, P=0.183) across the identified cohorts. The prevalence of Type 2 diabetes in psoriasis patients compared to controls was examined in 11 studies; all the 11 studies showed an increased prevalence of Type 2 diabetes compared to controls. The authors found however, that there was no correlation between Type 2 diabetes prevalence and psoriasis severity. Across the psoriasis cohorts there was no correlation between Type 2 diabetes prevalence and mean Psoriasis Area and Severity Index (PASI) (n=5, P=0.188).
Holm JG, Thomsen SF. Type 2 diabetes and psoriasis: links and risks. Psoriasis (Auckl). 2019;9:1-6.