Current advances in the science of innate immune defense are helping to further elucidate the role of P. acnes, sebocytes and keratinocytes in the development of acne.
Ilya Petrou, M.D.
The psychological distress caused by scarring and PIH following long-term acne disease can be devastating, begging the need for more effective therapeutic options.
Biofilms are increasingly implicated as the reason why currently available acne treatments sometimes prove ineffective in acne vulgaris patients, begging the need for more effective targeted therapies directed against biofilm formation.
Hidradenitis suppurativa (HS) is a challenging disease to treat; however, a better understanding of the disease and continued research has led to more clear-cut therapeutic options, according to an expert who spoke at the North American Clinical Dermatologic Society meeting.
Recent head-to-head clinical trial results with secukinumab (Novartis) and etanercept (Enbrel, Amgen) show a significant superiority of secukinumab in the treatment and management of patients with moderate-to-severe plaque psoriasis, perhaps heralding a new standard of care for this patient population.
Although the symptoms of acne and rosacea are well established, clear and definitive etiologies of these conditions have largely been unknown. Recent research, however, has shed new light into the pathophysiology of these conditions, paving the way for more targeted therapies.
While topical and oral therapies remain the gold standard approach for treating acne, laser and light sources are effective for acne lesions and scarring, and can be particularly useful in cases recalcitrant to standard therapeutic approaches.
The latest melanoma staging system from the American Joint Committee on Cancer (AJCC) and a tool developed for predicting the clinical outcome of individual patients with localized or regional cutaneous melanoma (www.melanomaprognosis.org) have stirred debate among dermatopathologists.
Merkel cell carcinoma (MCC) is a neuroendocrine tumor of the skin that is very aggressive and potentially lethal. As such, treatment approaches and disease management should also be aggressive and appropriately address the patient's disease and symptoms. Treatment choices depend on the stage of the tumor, however, as well as the general health of the affected patient.
With regard to the surgical treatment of androgenetic alopecia, strip harvesting and follicular unit extraction (FUE) techniques can work very well, but each technique must be used appropriately and for the appropriate patients to ensure optimal outcomes, says Walter Unger, M.D.