BIOLOGICAL BASIS FOR EFFICACY
NPS involves the delivery of low energy, high voltage, ultra-short (nanosecond) electrical pulses to the targeted lesion that ultimately results in regulated apoptotic cell death. It is postulated that the destruction of the lesion cells is accompanied by extracellular release of human papilloma viral specific antigens that subsequently trigger an immune response.
The observed resolution of untreated warts – a phenomenon that Dr. Munavalli refers to as a bystander effect – supports the idea that the mechanism of action of NPS for clearing warts involves activation of the host immune system.
“This immunomodulatory mechanism of action has been reported in the literature and through clinical observation with other destructive technologies and may not be unique to NPS. With NPS, however, there is a clear basis for understanding how immune activation can occur,” says Dr. Munavalli.
He adds that another important feature of NPS is that it is specific to cellular targets.
“NPS does not affect the dermal connective tissue, hair follicles, or blood vessels, and that is why we generally see good cosmetic results.”
Drs. Munavalli and Ross are investigators and members of the scientific advisory board for Pulse Biosciences.