Skip to main content
MJH Life Sciences
  • Login
  • Register
  • Login
  • Register
Home
  • Topics
  • Acne
  • Atopic Dermatitis
  • Psoriasis
  • Rosacea
  • Skin Cancer
  • Anti-Aging
  • NPPA Community
  • Derm Pulse
MJH Life Sciences

SUBSCRIBE: Print / Digital / eNewsletter

Ortho Dermatologics launches psoriasis topical

psoriasis topical

(Ольга Тернавская - stock.adobe.com)

  • Dermatology Times Staff
June 26, 2019
  • Psoriasis, Drug Development

Ortho Dermatologics announced that halobetasol propionate and tazarotene lotion, 0.01%/0.045% (Doubrii, Ortho Dermatologics) is now commercially available to healthcare providers, according to a press release issued June 25.

“The DUOBRII formulation brings together two well-known ingredients in a unique lotion vehicle with low concentrations of halobetasol propionate and tazarotene, into a single, first-of-its-kind topical treatment,” says Bill Humphries, president, Ortho Dermatologics.

Approved by the U.S. Food and Drug Administration in April 2019, the prescription topical’s combination of ingredients allows for uniform distribution and simultaneous skin surface contact, according to the company.

In a phase 2 multicenter, double-blind, randomized, vehicle controlled study, the lotion achieved more effective treatment success (at least a two-grade improvement from baseline in an Investigator Global Achievement score and “clear” or almost “clear skin”) when compared with its individual agents and vehicle. Investigators also reported that study participants showed a reduction in psoriasis signs, such as erythema, plaque elevation and scaling at target lesions.

Researchers of two phase 3 prospective, multi-center, randomized, double-blind clinical trials found that the topical was safe and effective in participants 18 years or older with moderate-to-severe psoriasis. A third phase 3 multicenter, open-label study evaluating the long-term safety over the course of a year found the most common treatment-related adverse evets were application site reactions such as itching, pain, irritation and folliculitis.

The lotion can be dosed to clearance as long as patients do not experience any local skin reactions; however, treatment should be stopped once clearance is achieved, the company states.

The topical is priced at $825 for a supply of a 100-gram tube.

Related Articles

Resource Topics rightRail

  • Resource Topics
  • Partner Content
  • Melasma and Hyperpigmentation Treatments
  • Treatments for Plaque Psoriasis
  • Derm Pulse
  • Current and Emerging Treatments for Acne
  • Videos Atopic Dermatitis
Treatment of Plaque Psoriasis
The management of Atopic Dermatitis Across the Generations
CME Activities
Advancements in Aesthetics Technology Podcast Series
Discovering the Versatility of the CO2RE Platform to Treat Dermatologic, Aesthetic, and Gynecologic Applications
Derm NP and PA discussion forum

Current Issue

Dermatology Times, December 2019 (Vol. 40, No. 12)
Dec 03, 2019 Vol 40 No 12
Digital Edition
Connect with Us
  • Column 1
    • Home
    • About Us
    • Contact Us
  • Column 2
    • Editorial Info
  • Column 3
    • Advertising Info
    • Reprints
    • Advertising Terms
  • Column 4
    • Terms of Use
    • Privacy Policy
Modern Medicine Network
© UBM 2019, All rights reserved.
Reproduction in whole or in part is prohibited.

We've noticed that you're using an ad blocker

Our content is brought to you free of charge because of the support of our advertisers. To continue enjoying our content, please turn off your ad blocker.

It's off now Dismiss How do I disable my ad blocker?
❌

How to disable your ad blocker for our site:

Adblock / Adblock Plus
  • Click on the AdBlock / AdBlock Plus icon on the top right of your browser.
  • Click “Don’t run on pages on this domain.” OR “Enabled on this site.”
  • Close this help box and click "It's off now".
Firefox Tracking Prevention
  • If you are Private Browsing in Firefox, "Tracking Protection" may casue the adblock notice to show. It can be temporarily disabled by clicking the "shield" icon in the address bar.
  • Close this help box and click "It's off now".
Ghostery
  • Click the Ghostery icon on your browser.
  • In Ghostery versions < 6.0 click “Whitelist site.” in version 6.0 click “Trust site.”
  • Close this help box and click "It's off now".
uBlock / uBlock Origin
  • Click the uBlock / uBlock Origin icon on your browser.
  • Click the “power” button in the menu that appears to whitelist the current website
  • Close this help box and click "It's off now".