Different preparations and dilutions of botulinum toxin type A can produce different results for relaxing facial muscles, as well as improve skin elasticity, pliability and re-organize facial collagen. Understanding those differences could have implications for improved clinical practice, according to industry experts.
The ability to use botulinum toxin type A to relax facial muscles and improve skin elasticity and pliability make it a highly sought-after treatment among patients. However, clinical evidence indicates not all types and concentrations provide the same results overall or in the same time frame.
In fact, a recent study published in the Journal of Cosmetic Dermatology revealed that using various botulinum toxin dilutions already actively employed in patient care can allow dermatologists to control and change the outcome for individual patients. But, for the best results, similar to a mild midfacial lift, providers should opt for less diluted toxins.
According to Rungsima Wanitphakdeedecha, M.D., lead study author, dermatologist and dermatologic surgeon based in Bangkok, Thailand, physicians should use this information in planning treatment and managing patient expectations.
“Although more diluted toxins may seem to produce better and faster fibroblast contraction,” she says, “in reality, more diluted toxins deliver lower total toxin dosages, thereby reducing toxin efficacy and longevity in clinical practice.”
The team posited that it was the fibroblast contraction itself that could be a potential mechanism for the positive lifting effect patients experience.