Across the study, a majority of patients experienced injection-site reactions, including swelling (75%), tenderness (75%), redness (72%), bruising (60%), pain (44%), itching (14%) and impaired hand function (7%). However, most reactions were reported as mild in intensity.
Notably, in weeks 4 through 24, the majority of patients demonstrated a slightly reduced flexion in both hands.
Based on natural variability of joint function measurements in the hand, “These results suggest that the negative change in active flexion for thumb for treated and untreated hands found through week 24 do not constitute a clinically detrimental effect on hand functionality,” the study authors report.
Furthermore, the numbers improved by the week 24 visit.
For those looking for safe and effective hand rejuvenation, this study provides clinical data demonstrating significant improvement in the appearance of dorsal hand volume through the use of HAL. With mostly mild adverse reactions and low adverse events, researchers documented stable improvements over the course of the study.
HAL treatments appear to provide a safe and affective option for increasing volume of the dorsal hand.
According to the article, the study and medical writing services were funded by Galderma Research and Development, LLC.
1. Wilkerson EC, Goldberg DJ. Small-Particle Hyaluronic Acid Gel Treatment of Photoaged Hands. Dermatol Surg. 2018;44(1):68-74.
2. Moradi A, Allen S, Bank D, et al. A Prospective, Multicenter, Randomized, Evaluator-Blinded, Split-Hand Study to Evaluate the Effectiveness and Safety of Large-Gel-Particle Hyaluronic Acid with Lidocaine for the Correction of Volume Deficits in the Dorsal Hand. Plast Reconstr Surg. 2019;144(4):586e-596e.