Approved in 2012 for patients 12 years and older for the treatment of acne vulgaris, the topical retinol tazarotene was recently relaunched in an aqueous foam formulation to mitigate the potential for skin irritation. The improved tolerability of the foam vehicle is meant to encourage patient compliance and increase satisfaction, according to the review.9
IN THE PIPELINE
And two topicals - an antiandrogen therapy and a cannabidiol formulation – are in the pipeline.
According to the review, researchers are exploring the use of clascoterone cream 1% for the treatment of moderate-to-severe acne in patients 9 years and older. The topical acts locally on androgen receptors in the skin to block the effects of circulating endogenous androgens.
“Chemically, it shares a 4-ring backbone identical to dihydrotestosterone and spironolactone,” says Dr. Kircik.
It’s well known that androgens influence both sebum production and inflammatory responses within the follicle, which contributes to the development of acne.10
“Antiandrogen therapy would, therefore, inhibit excess sebum production and directly reduce the presence of certain inflammatory mediators in skin. This effect is expected to lead to reduced follicular plugging and a reduction in growth of C. acnes and its inflammatory by-products,” says Dr Kircik.
1. Kircik LH. What's new in the management of acne vulgaris. Cutis. 2019;104(1):48-52.
2. Kang S, Cho S, Chung JH, Hammerberg C, Fisher GJ, Voorhees JJ. Inflammation and extracellular matrix degradation mediated by activated transcription factors nuclear factor-kappaB and activator protein-1 in inflammatory acne lesions in vivo. Am J Pathol. 2005;166(6):1691-9.
3. Leyden JJ, Sniukiene V, Berk DR, Kaoukhov A. Efficacy and Safety of Sarecycline, a Novel, Once-Daily, Narrow Spectrum Antibiotic for the Treatment of Moderate to Severe Facial Acne Vulgaris: Results of a Phase 2, Dose-Ranging Study. J Drugs Dermatol. 2018;17(3):333-338.
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7. Raoof J, Hooper D, Moore A, et al. FMX101 4% topical minocycline foam for the treatment of moderate to severe acne vulgaris: efficacy and safety from a phase 3 randomized, double-blind, vehicle-controlled study. Poster presented at: 2018 Fall Clinical Dermatology Conference; October 18-21, 2018; Las Vegas, NV.
8. Gold LS, Del Rosso JQ, Bhatia ND, et al. Efficacy and safety of FMX103 (1.5% minocycline foam) in the treatment of moderate-to-severe papulopustular rosacea: results from two phase 3 randomized, multicenter,
double-blind, vehicle-controlled studies. Poster presented at: 2019 Winter Clinical Dermatology Conference; January 18-23; 2019; Koloa, HI.
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10. Ju Q, Tao T, Hu T, Karadağ AS, Al-khuzaei S, Chen W. Sex hormones and acne. Clin Dermatol. 2017;35(2):130-137.
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12. Hebert A. Clascoterone topical cream, 1%: a novel, topical, local, selective androgen receptor antagonist: results from two phase 3 studies treating children and adult patients with facial acne vulgaris. Presented at: 2019 American Academy of Dermatology Annual Meeting; March 2, 2019; Washington, DC.
13. Oláh A, Tóth BI, Borbíró I, et al. Cannabidiol exerts sebostatic and antiinflammatory effects on human sebocytes. J Clin Invest. 2014;124(9):3713-24.
14. Wilkinson JD, Williamson EM. Cannabinoids inhibit human keratinocyte proliferation through a non-CB1/CB2 mechanism and have a potential therapeutic value in the treatment of psoriasis. J Dermatol Sci. 2007;45(2):87-92.
15. Appendino G, Gibbons S, Giana A, et al. Antibacterial cannabinoids from Cannabis sativa: a structure-activity study. J Nat Prod. 2008;71(8):1427-30.