Daylight photodynamic therapy is as effective in the short and long terms, as conventional photodynamic therapy for treatment of grade I and II face and scalp actinic keratoses, according to a recent study.
Patients also prefer daylight to conventional photodynamic. It’s better tolerated, nearly painless and less time consuming than conventional photodynamic therapy with 5-aminolevulinic or methylaminolevulinate cream, the authors found.
“Daylight photodynamic therapy is a relatively new, simplified procedure, in which daylight is used for the photosensitizer activation without requiring preliminary occlusion,” the authors write.
The researchers studied men and women older than 18 years with mild and moderate grade actinic keratoses on the face and scalp. Their study was conducted in three dermatology departments in Northern, Central and Southern Greece. Patients received either daylight, or conventional photodynamic therapy to alternate sides of their faces or scalps and were evaluated at baseline, three and twelve months post treatment.
At three months, the researchers report overall lesion complete response rates of 77.9 percent for daylight photodynamic therapy, versus 80.6 percent for conventional treatment. At a year post treatment, the overall complete response rate was 71.18 percent for daylight photodynamic therapy compared to 73.7 percent for conventional treatment. Overall recurrence rates from 3 to 12 months were 8.7 percent for daylight photodynamic therapy and 8 percent for conventional photodynamic therapy, which is not a statistically significant difference, according to the study.
Patient preference differences were significant between groups. More than 82 percent of patients preferred daylight photodynamic therapy and would prefer the option if they had to be retreated in the future. And for tolerance, nearly 87 percent of patients favored the daylight option.