Delivering stem cells
28-year-old female with sickle cell ulcer before and after treatment with CelluTome Epidermal Harvesting System
In chronic wounds such as diabetic ulcers, Dr. Kirsner said, the pathway by which factors released from the wound travel to the bone marrow and stimulate progenitor cells, causing stem cells to migrate to the wound, is perturbed. However, he said, case reports show that applying bone marrow-derived stem cells directly into a freshly debrided wound – via spray, injection or dressings – speeds healing while minimizing scarring.12
Similarly, one of the few RCTs in this area showed that placing MSCs into 18 diabetic ulcers led to statistically significant improvement versus placebo.13 As such, "There's a lot of potential here, using stem cells including bone marrow-derived stem cells to speed healing, and work is ongoing."